Microsporidiosis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare parasitic disease characterized by chronic diarrhea leading to severe weight loss caused by microsporidia contamination (most commonly by Encephalitozoon or Enterocytozoon). Contamination can occur through ingesting spores present in water or food or via direct human-to-human contact. Immunodeficient patients (such as individuals with HIV, and patients who have undergone a bone marrow or organ transplant) may be severely affected. These protozoan parasites mainly develop in intestinal cells, but can also be found in adipocytes, epithelial cells and blood cells.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Microsporidiosis | |
| fr | Microsporidiose | |
| de | Mikrosporidiose | |
| es | Microsporidiosis | |
| it | Microsporidiosi | |
| nl | Microsporidiose | |
| pt | Microsporidiose | |
| pl | Mikrosporydioza | |
| cs | Mikrosporidóza | |
| uk | Мікроспоридіоз | |
| zh | 微孢子虫病 | |
| tr | Mikrosporidioz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B60.8 | NTBT | inclusion | validated |
| ICD-11 | 1F58 | E | specific | validated |
| MONDO | 0005846 | E | validated | |
| MeSH | D016881 | E | validated | |
| UMLS | C0085407 | E | validated | |
| GARD | 3655 | E | validated | |
| MedDRA | 10053982 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163588Rare parasitic disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
51 annotations · validated 2019-10-25| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0002028 | Chronic diarrhea | |
| HP:0032218 | Decreased proportion of CD4-positive T cells | |
| HP:0002721 | Immunodeficiency | |
| HP:0002254 | Intermittent diarrhea | |
| HP:0001824 | Weight loss | |
| Occasional (29-5%) | ||
| HP:0011277 | Abnormality of the urinary system physiology | |
| HP:0002039 | Anorexia | |
| HP:0012387 | Bronchitis | |
| HP:0001945 | Fever | |
| HP:0002018 | Nausea | |
| HP:0012384 | Rhinitis | |
| HP:0000246 | Sinusitis | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0002778 | Abnormal trachea morphology | |
| HP:0008777 | Abnormal vocal cord morphology | |
| HP:0005561 | Abnormality of bone marrow cell morphology | |
| HP:0030126 | Abnormality of the endometrium | |
| HP:0011027 | Abnormality of the fallopian tube | |
| HP:0000828 | Abnormality of the parathyroid gland | |
| HP:0001743 | Abnormality of the spleen | |
| HP:0000849 | Adrenocortical abnormality | |
| HP:0001080 | Biliary tract abnormality | |
| HP:0030049 | Brain abscess | |
| HP:0011950 | Bronchiolitis | |
| HP:0004326 | Cachexia | |
| HP:0030151 | Cholangitis | |
| HP:0012804 | Corneal ulceration | |
| HP:0001944 | Dehydration | |
| HP:0100584 | Endocarditis | |
| HP:0000206 | Glossitis | |
| HP:0012115 | Hepatitis | |
| HP:0002383 | Infectious encephalitis | |
| HP:0000491 | Keratitis | |
| HP:0001096 | Keratoconjunctivitis | |
| HP:0002840 | Lymphadenitis | |
| HP:0012819 | Myocarditis | |
| HP:0100614 | Myositis | |
| HP:0000123 | Nephritis | |
| HP:0002754 | Osteomyelitis | |
| HP:0001733 | Pancreatitis | |
| HP:0002586 | Peritonitis | |
| HP:0025439 | Pharyngitis | |
| HP:0002090 | Pneumonia | |
| HP:0000024 | Prostatitis | |
| HP:0001250 | Seizure | |
| HP:0100806 | Sepsis | |
| HP:0200036 | Skin nodule | |
| HP:0100646 | Thyroiditis | |
| HP:0500006 | Urethritis | |
| HP:0000572 | Visual loss | |
Annotation source: 20702053[PMID]_24829239[PMID]_26004651[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/2552
- This record as JSON: /data/d/2552.json