Baló concentric sclerosis
Synonyms: Concentric demyelination
- Type
- Disease
- Group
- Disorder
- Inheritance
- Multigenic/multifactorial
- Age of onset
- Adult
- Status
- active
A rare multiple sclerosis variant characterized by discrete concentrically layered, ring-like lesions in the cerebral white matter, consisting of alternating layers of myelinated and demyelinated tissue. Patients most commonly present with symptoms of an intracerebral mass lesion, including headache, cognitive abnormalities, behavioral changes, seizures, aphasia, or hemiparesis, among others, although there may also be classic focal symptoms of multiple sclerosis, such as focal weakness, ataxia, sensory disturbance, or diplopia.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Baló concentric sclerosis | Concentric demyelination |
| fr | Sclérose concentrique de Baló | Démyélinisation concentrique |
| de | Konzentrische Sklerose Baló | Baló-Krankheit · Demyelinisierung, konzentrische |
| es | Esclerosis concéntrica de Baló | Desmielinización concéntrica |
| it | Sclerosi concentrica di Baló | Demielinizzazione concentrica |
| nl | Concentrische sclerose van Baló | Concentrische demyelinisatie |
| pt | Esclerose concêntrica de Balò | |
| pl | Stwardnienie koncentryczne Baló | Demielinizacja koncentryczna |
| cs | Balóova koncentrická skleróza | Koncentrická demyelinizace |
| uk | Концентричний склероз Бало | Концентрична демієлінізація |
| zh | 同心圆性硬化 | 同心圆性脱髓鞘 |
| tr | Balo'nun konsantrik skleroz | Konsantrik demiyelinizasyon |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G37.5 | E | specific | validated |
| ICD-11 | 8A40.Y | NTBT | index | validated |
| MONDO | 0016430 | E | validated | |
| UMLS | C0004712 | E | validated | |
| GARD | 5885 | E | validated | |
| MedDRA | 10010252 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:228145Multiple sclerosis variant
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/228165
- This record as JSON: /data/d/228165.json