Acquired hypertrichosis lanuginosa
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A rare cutaneous paraneoplastic disease characterized by the presence of excessive lanugo-type hair on the glabrous skin of face, neck, trunk and limbs that can be associated with additional clinical features such as burning glossitis, papillary hypertrophy of the tongue, diarrhea, dysgeusia, and/or weight loss. It is associated with lymphoma or cancer of the gastrointestinal system, urinary tract, lung, breast, uterus or ovary.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acquired hypertrichosis lanuginosa | |
| fr | Hypertrichose lanugineuse acquise | |
| de | Hypertrichosis lanuginosa, erworbene | |
| es | Hipertricosis lanuginosa adquirida | |
| it | Ipertricosi lanuginosa acquisita | |
| nl | Verworven hypertrichosis lanuginosa | |
| pt | Hipertricose lanuginosa adquirida | |
| pl | Nabyte nadmierne owłosienie typu płodowego | |
| cs | Získaná lanuginózní hypertrichóza | |
| uk | Набутий гіпертрихоз ланугіноз | |
| zh | 获得性胎毛增多症 | |
| tr | Edinsel hipertrikoz lanuginoza |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | L68.1 | E | specific | validated |
| ICD-11 | EL10 | NTBT | index | validated |
| MONDO | 0016380 | E | validated | |
| UMLS | C0343072 | E | validated | |
| GARD | 2864 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:79365Rare disorder with hypertrichosis
rare skin diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 60 cases | Worldwide | Case(s) | Validated | ORPHANET | |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
18 annotations · validated 2017-09-27| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000534 | Abnormal eyebrow morphology | |
| HP:0000492 | Abnormal eyelid morphology | |
| HP:0002213 | Fine hair | |
| HP:0002230 | Generalized hirsutism | |
| HP:0005599 | Hypopigmentation of hair | |
| HP:0002664 | Neoplasm | |
| Frequent (79-30%) | ||
| HP:0000206 | Glossitis | |
| HP:0000158 | Macroglossia | |
| Occasional (29-5%) | ||
| HP:0000956 | Acanthosis nigricans | |
| HP:0002028 | Chronic diarrhea | |
| HP:0008064 | Ichthyosis | |
| HP:0002716 | Lymphadenopathy | |
| HP:0100013 | Neoplasm of the breast | |
| HP:0100606 | Neoplasm of the respiratory system | |
| HP:0100615 | Ovarian neoplasm | |
| HP:0004396 | Poor appetite | |
| HP:0001072 | Thickened skin | |
| HP:0001824 | Weight loss | |
Run the differential on the 6 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/2221
- This record as JSON: /data/d/2221.json