Lymphatic filariasis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Lymphatic filariasis (LF) is a severe form of filariasis, caused by the parasitic worms <i>Wuchereria bancrofti</i>, <i>Brugia malayi</i> and <i>Brugia timori</i>, and the most common cause of acquired lymphedema worldwide. LF is endemic to tropical and subtropical regions. The vast majority of infected patients are asymptomatic but it can also cause a variety of clinical manifestations, including limb lymphedema, genital anomalies (hydrocele, chylocele), elephantiasis in later stages of the disease (frequently in the lower extremities), and tropical pulmonary eosinophilia (nocturnal paroxysmal cough and wheezing, weight loss, low-grade fever, adenopathy, and pronounced blood eosinophilia). Renal involvement (hematuria, proteinuria, nephritic syndrome, glomerulonephritis), and mono-arthritis of the knee or ankle joint have also been reported.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Lymphatic filariasis | |
| fr | Filariose lymphatique | |
| de | Lymphatische Filariose | |
| es | Filariasis linfática | |
| it | Filariosi linfatica | |
| nl | Lymfatische filariasis | |
| pt | Filariose linfática | |
| pl | Filarioza limfatyczna | |
| cs | Lymfatická filarióza | |
| uk | Лімфатичний філяріоз | |
| zh | 淋巴性丝虫病 | |
| tr | Lenfatik filaryaz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B74.0 | BTNT | specific | validated |
| ICD-10 | B74.1 | BTNT | specific | validated |
| ICD-10 | B74.2 | BTNT | specific | validated |
| ICD-11 | 1F66.3 | E | specific | validated |
| ICD-11 | 1F66.30 | BTNT | specific | validated |
| ICD-11 | 1F66.31 | BTNT | specific | validated |
| ICD-11 | 1F66.32 | BTNT | specific | validated |
| UMLS | C0013884 | E | validated | |
| GARD | 3321 | E | validated | |
| MedDRA | 10016675 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:2034Filariasis
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | >1 / 1000 | — | Specific population | Class only | Validated | World Health Organization[OTHER] |
| Point prevalence | <1 / 1 000 000 | — | Europe | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
33 annotations · validated 2020-04-09| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0100763 | Abnormality of the lymphatic system | |
| HP:0002716 | Lymphadenopathy | |
| HP:0001004 | Lymphedema | |
| HP:0003550 | Predominantly lower limb lymphedema | |
| Frequent (79-30%) | ||
| HP:0012224 | Circulating immune complexes | |
| HP:0012378 | Fatigue | |
| HP:0032061 | Hypereosinophilia | |
| HP:0000962 | Hyperkeratosis | |
| HP:0000953 | Hyperpigmentation of the skin | |
| HP:0002840 | Lymphadenitis | |
| HP:0012531 | Pain | |
| Occasional (29-5%) | ||
| HP:0002088 | Abnormal lung morphology | |
| HP:0000077 | Abnormality of the kidney | |
| HP:0000045 | Abnormality of the scrotum | |
| HP:0012735 | Cough | |
| HP:0001945 | Fever | |
| HP:0000034 | Hydrocele testis | |
| HP:0031842 | Lymphangiectasis | |
| HP:0032260 | Opportunistic bacterial infection | |
| HP:0031690 | Opportunistic infection | |
| HP:0100796 | Orchitis | |
| HP:0002091 | Restrictive ventilatory defect | |
| HP:0100673 | Vaginal hydrocele | |
| HP:0030828 | Wheezing | |
| Very rare (<4-1%) | ||
| HP:0001785 | Ankle swelling | |
| HP:0000031 | Epididymitis | |
| HP:0000099 | Glomerulonephritis | |
| HP:0000790 | Hematuria | |
| HP:0005086 | Knee osteoarthritis | |
| HP:0000100 | Nephrotic syndrome | |
| HP:0008763 | No social interaction | |
| HP:0000093 | Proteinuria | |
| HP:0000796 | Urethral obstruction | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 31027660[PMID]_31312785[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/2035
- This record as JSON: /data/d/2035.json