Ledderhose disease
Synonyms: Plantar fibromatosis
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adult
- Status
- active
A rare, benign, superficial fibromatosis disease characterized by single or multiple, uni- or bilateral, slow-growing, round, firm nodules typically located on the medial portion of the plantar aponeurosis, with no calcification. Patients are often asymptomatic or may present with foot pain, difficulty to walk or stand and, rarely, toe contractures. Histopathology reveals dense fibrocellular tissue with parallel and nodular arrays of fibrocytes and fibrillar collagen with a distinctive cork-screw morphology and no atypia.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Ledderhose disease | Plantar fibromatosis |
| fr | Maladie de Ledderhose | Fibromatose plantaire |
| de | Ledderhose-Krankheit | Fibromatose, plantare |
| es | Enfermedad de Ledderhose | Fibromatosis plantar |
| it | Malattia di Ledderhose | Fibromatosi plantare |
| nl | Ziekte van Ledderhose | Plantaire fibromatose |
| pt | Doença Ledderhose | Fibromatose plantar |
| pl | Choroba Ledderhose'a | Włokniakowatość podeszwowa |
| cs | Ledderhosův syndrom | Plantární fibromatóza · Ledderhoseova nemoc |
| uk | Хвороба Леддерхауза | Підошовний фіброматоз |
| zh | Ledderhose 病 | 跖腱膜纤维瘤病 |
| tr | Ledderhose hastalığı | Plantar fibromatoz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | M72.2 | E | specific | validated |
| ICD-11 | FB51.Y | NTBT | index | validated |
| MONDO | 0004684 | E | validated | |
| MeSH | D000071380 | E | validated | |
| UMLS | C0158360 | E | validated | |
| GARD | 6873 | E | validated | |
| MedDRA | 10035154 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:199257Superficial fibromatosis
rare skin diseases; rare neoplastic diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
5 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002829 | Arthralgia | |
| HP:0100679 | Lack of skin elasticity | |
| HP:0003401 | Paresthesia | |
| Frequent (79-30%) | ||
| HP:0001482 | Subcutaneous nodule | |
| Occasional (29-5%) | ||
| HP:0009830 | Peripheral neuropathy | |
Run the differential on the 3 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/199251
- This record as JSON: /data/d/199251.json