Diabetic embryopathy
Synonyms: Diabetes-induced teratogenicity
- Type
- Malformation syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Antenatal, Neonatal
- Status
- active
A rare teratologic disease characterized by a range of congenital anomalies associated with poorly controlled maternal diabetes, frequently including abnormalities of the cardiovascular or central nervous system as well as other organ systems, such as skeletal and craniofacial systems. In addition to embryopathy, uncontrolled maternal diabetes can lead to fetal/neonatal complications (including metabolic, respiratory or delivery complications).
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Diabetic embryopathy | Diabetes-induced teratogenicity |
| fr | Embryopathie diabétique | |
| de | Diabetische Embryopathie | Diabetes-induzierte Teratogenität · Diabetische Fetopathie · Embryopathia diabetica |
| es | Embriopatía diabética | Teratogenicidad inducida por diabetes |
| it | Embriopatia diabetica | Teratogenicità indotta dal diabete |
| nl | Diabetische embryopathie | Door diabetes geïnduceerde teratogeniciteit |
| pt | Embriopatia diabética | |
| pl | Embriopatia cukrzycowa | = en |
| cs | Diabetická embryopatie | = en |
| uk | Діабетична ембріопатія | |
| zh | 糖尿病性胚胎病 | |
| tr | Diyabetik embriyopati |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | P70.1 | NTBT | attributed | validated |
| ICD-11 | KB60.1 | NTBT | index | validated |
| MONDO | 0016018 | E | validated | |
| UMLS | C3830518 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (4):
- ORPHA:251535Maternal disease-related embryofetopathy
rare developmental anomalies during embryogenesis; rare teratologic disorders - ORPHA:217598Non-familial hypertrophic cardiomyopathy
rare cardiac diseases; rare transplant-related disorders - ORPHA:93460Overgrowth syndrome
rare developmental anomalies during embryogenesis - ORPHA:138059Teratogenic Pierre Robin syndrome
rare developmental anomalies during embryogenesis; rare otorhinolaryngological diseases; rare surgical maxillo-facial diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
32 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001679 | Abnormal aortic morphology | |
| HP:0030680 | Abnormal cardiovascular system morphology | |
| HP:0000008 | Abnormal morphology of female internal genitalia | |
| HP:0005107 | Abnormal sacrum morphology | |
| HP:0000464 | Abnormality of the neck | |
| HP:0004414 | Abnormality of the pulmonary artery | |
| HP:0008056 | Aplasia/Hypoplasia affecting the eye | |
| HP:0010318 | Aplasia/Hypoplasia of the abdominal wall musculature | |
| HP:0000175 | Cleft palate | |
| HP:0000028 | Cryptorchidism | |
| HP:0000126 | Hydronephrosis | |
| HP:0000252 | Microcephaly | |
| HP:0000054 | Micropenis | |
| HP:0008551 | Microtia | |
| HP:0000358 | Posteriorly rotated ears | |
| HP:0008678 | Renal hypoplasia/aplasia | |
| HP:0001636 | Tetralogy of Fallot | |
| HP:0001669 | Transposition of the great arteries | |
| HP:0000073 | Ureteral duplication | |
| HP:0001629 | Ventricular septal defect | |
| HP:0003422 | Vertebral segmentation defect | |
| Frequent (79-30%) | ||
| HP:0000707 | Abnormality of the nervous system | |
| HP:0007360 | Aplasia/Hypoplasia of the cerebellum | |
| HP:0007370 | Aplasia/Hypoplasia of the corpus callosum | |
| HP:0002007 | Frontal bossing | |
| HP:0000365 | Hearing impairment | |
| HP:0000238 | Hydrocephalus | |
| HP:0000347 | Micrognathia | |
| HP:0001195 | Single umbilical artery | |
| HP:0010301 | Spinal dysraphism | |
| HP:0000098 | Tall stature | |
| Occasional (29-5%) | ||
| HP:0001732 | Abnormality of the pancreas | |
Run the differential on the 12 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1926
- This record as JSON: /data/d/1926.json