Fetal minoxidil syndrome
Synonyms: Minoxidil antenatal exposure
- Type
- Malformation syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Antenatal, Neonatal
- Status
- active
Fetal minoxidil syndrome is characterized by a group of symptoms that may be observed in a fetus or newborn when the mother has taken minoxidil during pregnancy. Minoxidil is used in the treatment of malignant renal hypertension and as a topical solution to induce scalp hair growth. Hypertrichosis that gradually diminishes during the first six postnatal months has been reported. Additional reported features include cardiac (congenital great vessel transposition and pulmonary valve stenosis), neurodevelopmental (caudal regression sequence), gastrointestinal, renal, and limb malformations. Conclusive studies are however not available.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Fetal minoxidil syndrome | Minoxidil antenatal exposure |
| fr | Embryopathie au minoxidil | Exposition anténatale au minoxidil |
| de | Minoxidil-Embryopathie | Fetales Minoxidil-Syndrom · Minoxidil-Exposition, vorgeburtliche |
| es | Síndrome fetal por minoxidil | Exposición prenatal a minoxidil |
| it | Sindrome fetale da minoxidil | Esposizione prenatale al minoxidil |
| nl | Foetaal minoxidilsyndroom | Prenatale blootstelling aan inoxidil |
| pt | Síndrome de minoxidil fetal | Exposição prénatal ao minoxidil |
| pl | Płodowy zespół minoksydylowy | Minoxidil antenatal infection |
| cs | Fetální minoxidilový syndrom | = en |
| uk | Фетальний міноксіділовий синдром | Антенатальна експозиція міноксидилу |
| zh | 胎儿米诺地尔综合征 | 米诺地尔所致产前感染 |
| tr | Fetal minoksidil sendromu | Minoksidil antenatal enfeksiyon |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | Q86.8 | NTBT | attributed | validated |
| ICD-11 | LD2F.0Y | NTBT | index | validated |
| MONDO | 0016014 | E | validated | |
| UMLS | C0432373 | E | validated | |
| GARD | 2308 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:138059Teratogenic Pierre Robin syndrome
rare developmental anomalies during embryogenesis; rare otorhinolaryngological diseases; rare surgical maxillo-facial diseases - ORPHA:251529Toxic or drug-related embryofetopathy
rare developmental anomalies during embryogenesis; rare disorders due to toxic effects; rare teratologic disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
8 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0004209 | Clinodactyly of the 5th finger | |
| HP:0000028 | Cryptorchidism | |
| HP:0005280 | Depressed nasal bridge | |
| HP:0002230 | Generalized hirsutism | |
| HP:0000347 | Micrognathia | |
| HP:0000358 | Posteriorly rotated ears | |
| HP:0001537 | Umbilical hernia | |
| HP:0001629 | Ventricular septal defect | |
Run the differential on the 8 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1918
- This record as JSON: /data/d/1918.json