Cocaine embryofetopathy
Synonyms: Fetal cocaine syndrome
- Type
- Malformation syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Antenatal, Neonatal
- Status
- active
Cocaine embryofetopathy is a group of clinical signs observed in newborns exposed <i>in utero</i> to cocaine, a short-acting central nervous system stimulant used as a recreational drug through inhalation of the powder or intravenous injection. Cocaine use during pregnancy is associated with intrauterine growth restriction, low birth weight, seizures, respiratory distress (decreased apnea density and periodic breathing), feeding difficulties, irritability and lability of state, decreased behavioral and autonomic regulation, poor alertness and orientation and cognitive impairment (impaired auditory information processing , visual-spatial delay and subtle language delay) in the offspring.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Cocaine embryofetopathy | Fetal cocaine syndrome |
| fr | Embryofoetopathie à la cocaïne | Exposition anténatale à la cocaïne |
| de | Kokain-Embryofetopathie | Fetales Kokain-Syndrom · Kokain-Exposition, vorgeburtliche |
| es | Embriopatía por cocaína | Exposición fetal a la cocaína |
| it | Embriofetopatia da cocaina | Esposizione prenatale alla cocaina |
| nl | Cocaïne-embryofoetopathie | Foetaal cocaïnesyndroom |
| pt | Embriofetopatia por cocaína | Síndrome de cocaína fetal |
| pl | Embriofetopatia kokainowa | Płodowy zespół kokainowy |
| cs | Kokainová embryofetopatie | Fetální kokainový syndrom |
| uk | Кокаїнова ембріофетопатія | Кокаїновий синдром плода |
| zh | 可卡因胚胎胎儿病 | 胎儿可卡因综合征 |
| tr | Kokain embriyofetopatisi | fetal kokain sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | Q86.8 | NTBT | attributed | validated |
| ICD-11 | LD2F.0Y | NTBT | index | validated |
| MONDO | 0016007 | E | validated | |
| UMLS | C0432371 | E | validated | |
| GARD | 1413 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:138059Teratogenic Pierre Robin syndrome
rare developmental anomalies during embryogenesis; rare otorhinolaryngological diseases; rare surgical maxillo-facial diseases - ORPHA:251529Toxic or drug-related embryofetopathy
rare developmental anomalies during embryogenesis; rare disorders due to toxic effects; rare teratologic disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
8 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001347 | Hyperreflexia | |
| HP:0001276 | Hypertonia | |
| Occasional (29-5%) | ||
| HP:0001626 | Abnormality of the cardiovascular system | |
| HP:0000079 | Abnormality of the urinary system | |
| HP:0100657 | Celosomia | |
| HP:0002084 | Encephalocele | |
| HP:0011100 | Intestinal atresia | |
| HP:0009882 | Short distal phalanx of finger | |
Run the differential on the 2 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1911
- This record as JSON: /data/d/1911.json