Fetal iodine syndrome
- Type
- Malformation syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Antenatal, Neonatal
- Status
- active
Fetal iodine syndrome refers to symptoms and signs that may be observed in a fetus or newborn when the mother was exposed during pregnancy to inappropriate (insufficient or excessive) amounts of iodine. Iodine deficiency is associated with goiter and hypothyroidism. When severe iodine deficiency occurs during pregnancy, it is associated with congenital hypothyroidism that is manifested by increased neonatal morbi-mortality and severe mental dysfunction, hyperactivity, attention disorders and a substantial decrease of IQ of an irreversible nature. Excessive iodine ingestion during the third trimester of pregnancy can result in hypothyroidism and fetal goiter due to a prolonged inhibition of thyroid hormone synthesis, an increase in thyrotropin (TSH).
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Fetal iodine syndrome | |
| fr | Hypothyroïdie congénitale par insuffisance/excès d'apport en iode | |
| de | Jodmangelsyndrom, fetales | Kongenitale Hypothyreose durch Jodmangel/Jodüberschuss |
| es | Síndrome por exposición fetal a la iodina | |
| it | Fetopatia da iodio | |
| nl | Foetaal jodiumsyndroom | |
| pt | Síndrome iodo fetal | |
| pl | Płodowy zespół jodowy | |
| cs | Fetální jodový syndrom | |
| uk | Фетальний йодний синдром | |
| zh | 胎儿碘综合征 | |
| tr | Fetal iyot sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 228355 | E | validated | |
| ICD-10 | P72.2 | NTBT | attributed | validated |
| ICD-11 | 5A00.03 | NTBT | index | validated |
| MONDO | 0009224 | E | validated | |
| UMLS | C4273860 | E | validated | |
| GARD | 2304 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (3):
- ORPHA:138059Teratogenic Pierre Robin syndrome
rare developmental anomalies during embryogenesis; rare otorhinolaryngological diseases; rare surgical maxillo-facial diseases - ORPHA:251529Toxic or drug-related embryofetopathy
rare developmental anomalies during embryogenesis; rare disorders due to toxic effects; rare teratologic disorders - ORPHA:238696Transient congenital hypothyroidism due to maternal factor
rare endocrine diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
7 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0004374 | Hemiplegia/hemiparesis | |
| HP:0001249 | Intellectual disability | |
| HP:0000407 | Sensorineural hearing impairment | |
| HP:0001264 | Spastic diplegia | |
| Frequent (79-30%) | ||
| HP:0000821 | Hypothyroidism | |
| Occasional (29-5%) | ||
| HP:0000639 | Nystagmus | |
| HP:0000486 | Strabismus | |
Run the differential on the 4 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1910
- This record as JSON: /data/d/1910.json