Indomethacin embryofetopathy
Synonyms: Fetal indomethacin syndrome
- Type
- Malformation syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Antenatal, Neonatal
- Status
- active
Indomethacin embryofetopathy refers to the manifestations that may be observed in a fetus or newborn when the mother has taken indomethacin, a potent prostaglandin inhibitor and tocolytic agent that can cross placenta, during pregnancy. Reported adverse fetal/neonatal effects include decreased renal function resulting in oligohydramnios, closure of the ductus arteriosus, and delayed cardiovascular adaptation at birth. These effects are usually transient and reversible. Indomethacin may also be a risk factor for cerebral injury (periventricular leukomalacia) and necrotizing enterocolitis in preterm infants.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Indomethacin embryofetopathy | Fetal indomethacin syndrome |
| fr | Embryofoetopathie à l'indométacine | Exposition anténatale à l'indometacine |
| de | Indometacin-Embryopathie | Indometacin-Exposition, vorgeburtliche · Indomethacin-Embryofetopathie |
| es | Embriopatía por indometacina | Exposición fetal a la indometacina |
| it | Embrio/fetopatia da indometacina | Esposizione prenatale all'indometacina |
| nl | Indometacine-embryofoetopathie | Foetaal indometacinesyndroom |
| pt | Embriofetopatia por indometacina | Síndrome indometacina fetal |
| pl | Embriofetopatia indometacynowa | Płodowy zespół indometacynowy |
| cs | Indometacinová embryofetopatie | Fetální indometacinový syndrom |
| uk | Індометацинова ембріофетопатія | Синдром індометацину у плода |
| zh | 吲哚美辛胚胎胎儿病 | 胎儿吲哚美辛综合征 |
| tr | İndometasin embriyofetopatisi | fetal indometasin sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | Q86.8 | NTBT | attributed | validated |
| ICD-11 | LD2F.0Y | NTBT | index | validated |
| MONDO | 0016005 | E | validated | |
| UMLS | C4275138 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:138059Teratogenic Pierre Robin syndrome
rare developmental anomalies during embryogenesis; rare otorhinolaryngological diseases; rare surgical maxillo-facial diseases - ORPHA:251529Toxic or drug-related embryofetopathy
rare developmental anomalies during embryogenesis; rare disorders due to toxic effects; rare teratologic disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
12 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000112 | Nephropathy | |
| HP:0001622 | Premature birth | |
| HP:0000083 | Renal insufficiency | |
| HP:0002093 | Respiratory insufficiency | |
| Occasional (29-5%) | ||
| HP:0000091 | Abnormal renal tubule morphology | |
| HP:0001928 | Abnormality of coagulation | |
| HP:0001631 | Atrial septal defect | |
| HP:0001638 | Cardiomyopathy | |
| HP:0001789 | Hydrops fetalis | |
| HP:0000003 | Multicystic kidney dysplasia | |
| HP:0001562 | Oligohydramnios | |
| HP:0001629 | Ventricular septal defect | |
Run the differential on the 4 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/1909
- This record as JSON: /data/d/1909.json