Atopic keratoconjunctivitis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare, chronic allergic disease of the cornea and conjunctiva occurring in all age groups, characterized by severe itching and burning sensation, conjunctival injection, photophobia and edema with serious cases leading to ulceration of the cornea which can result in blindness. It is often associated with atopic dermatitis.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Atopic keratoconjunctivitis | |
| fr | Kératoconjonctivite atopique | |
| de | Keratokonjunktivitis, atopische | |
| es | Queratoconjuntivitis atópica | |
| it | Cheratocongiuntivite atopica | |
| nl | Atopische keratoconjunctivitis | |
| pt | Queratoconjuntivite atópica | |
| pl | Atopowe zapalenie spojówek i rogówki | |
| cs | Atopická keratokonjunktivitida | |
| uk | Атопічний кератоконюнктивіт | |
| zh | 特应性角膜结膜炎 | |
| tr | Atopik keratokonjunktivit |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | H16.2 | NTBT | attributed | validated |
| ICD-11 | 9A60.0Y | NTBT | index | validated |
| MONDO | 0015599 | E | validated | |
| UMLS | C1274788 | E | validated | |
| MedDRA | 10069664 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:519280Rare conjunctivitis
rare ophthalmic disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 15 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2009[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
15 annotations · validated 2023-09-12| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0007957 | Corneal opacity | |
| HP:0000958 | Dry skin | |
| HP:0000491 | Keratitis | |
| HP:0001097 | Keratoconjunctivitis sicca | |
| Frequent (79-30%) | ||
| HP:0000492 | Abnormal eyelid morphology | |
| HP:0007879 | Allergic conjunctivitis | |
| HP:0000498 | Blepharitis | |
| HP:0000622 | Blurred vision | |
| HP:0030953 | Conjunctival hyperemia | |
| HP:0011496 | Corneal neovascularization | |
| HP:0011457 | Loss of eyelashes | |
| HP:0200026 | Ocular pain | |
| HP:0000613 | Photophobia | |
| Occasional (29-5%) | ||
| HP:0012375 | Chemosis | |
| HP:0000559 | Corneal scarring | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 26278858[PMID]_28846256[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/163934
- This record as JSON: /data/d/163934.json