Herpes simplex virus stromal keratitis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Herpes simplex (HSV) stromal keratitis is an infectious ocular disease of either necrotizing or non-necrotizing form, due to an HSV infection, and characterized by corneal stromal necrosis, inflammation, ulceration and infiltration by leukocytes. Corneal perforation and blindness can also occur in severe cases.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Herpes simplex virus stromal keratitis | |
| fr | Kératite stromale à herpes simplex | Kératite stromale herpétique |
| de | Herpes simplex-Stromakeratitis | HSV-Stromakeratitis · Stromakeratitis, herpetische |
| es | Queratitis estromal | |
| it | Cheratite stromale | |
| nl | Herpes-simplexvirus stromale keratitis | |
| pt | Queratite do estroma por herpes simplex virus | |
| pl | Zapalenie zrębu rogówki | |
| cs | Stromální keratitida | |
| uk | Стромальний кератит, спричинений вірусом простого герпесу | |
| zh | 单纯疱疹病毒角膜基质炎 | |
| tr | Herpes simpleks virüsü stromal keratiti |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | H16.3 | NTBT | attributed | validated |
| ICD-11 | 1F00.10 | NTBT | index | validated |
| MONDO | 0015291 | E | validated | |
| UMLS | C1301533 | E | validated | |
| GARD | 19879 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:519278Infective keratitis
rare ophthalmic disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 4.2091 / 100 000 | Worldwide | Value and class | Validated | 32732703[PMID]_34622738[PMID]_33607690[PMID]_3391390[PMID] |
| Annual incidence | 1-9 / 100 000 | 5.4 / 100 000 | France | Value and class | Validated | 22944008[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
17 annotations · validated 2023-09-12| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012040 | Corneal stromal edema | |
| HP:0007765 | Deep anterior chamber | |
| HP:0012108 | Open angle glaucoma | |
| HP:0007663 | Reduced visual acuity | |
| Frequent (79-30%) | ||
| HP:0000622 | Blurred vision | |
| HP:0030953 | Conjunctival hyperemia | |
| HP:0100583 | Corneal perforation | |
| HP:0012155 | Decreased corneal sensation | |
| HP:0012039 | Descemet Membrane Folds | |
| HP:0009926 | Epiphora | |
| HP:0007812 | Herpetiform corneal ulceration | |
| HP:0031448 | Herpetiform vesicles | |
| HP:0007906 | Ocular hypertension | |
| Occasional (29-5%) | ||
| HP:0000618 | Blindness | |
| HP:0000491 | Keratitis | |
| HP:0011134 | Low-grade fever | |
| HP:0033834 | Malaise | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 31424862[PMID]_26989540[PMID]_27221681[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/137599
- This record as JSON: /data/d/137599.json