Neonatal hypoxic and ischemic brain injury
Synonyms: HIE · Hypoxic and ischemic brain injury in the newborn · Hypoxic-ischemic encephalopathy · Perinatal hypoxia
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Infancy, Neonatal
- Status
- active
A rare neonatal encephalopathy characterized by alterations in mental status ranging from irritability and decreased responsiveness to coma, as well as abnormal primitive reflexes, hypotonia, seizures, and abnormalities in feeding and respiration, with an onset within the first hours of life. The condition is associated with high mortality. Long-term sequelae include a spectrum of signs and symptoms including behavioral deficits, developmental delay, learning disabilities, cognitive impairment, seizures, visual and auditory dysfunction, and cerebral palsy.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Neonatal hypoxic and ischemic brain injury | HIE · Hypoxic and ischemic brain injury in the newborn · Hypoxic-ischemic encephalopathy · Perinatal hypoxia |
| fr | Lésion cérébrale ischémique et hypoxique néonatale | Encéphalopathie hypoxique-ischémique · Hypoxie périnatale · Lésion cérébrale ischémique et hypoxique du nouveau-né |
| de | Hypoxische und ischämische Hirnverletzung des Neugeborenen | HIE · Hypoxisch-ischämische Enzephalopathie · Hypoxische und ischämische Hirnschäden bei Neugeborenen · Perinatale Hypoxie |
| es | Lesión hipóxico-isquémica cerebral neonatal | EHI · Encefalopatía hipóxico-isquémica · Hipoxia perinatal |
| it | Danno cerebrale neonatale ipossico e ischemico | Danno cerebrale ipossico e ischemico nel neonato · Encefalopatia ipossico-ischemica · HIE · Ipossia perinatale |
| nl | Neonataal hypoxisch en ischemisch hersenletsel | HIE · Hypoxisch en ischemisch hersenletsel bij neonaat · Hypoxisch-ischemische encefalopathie · Perinatale hypoxie |
| pt | Lesão cerebral hipóxico-isquémica neonatal | Encefalopatia hipóxico-isquémica · HIE · Hipóxia perinatal · Lesão cerebral hipóxico-isquémica do recém-nascido |
| pl | Uszkodzenie mózgu noworodka z powodu niedotlenienia i niedokrwienia | Encefalopatia niedotleniowo-niedokrwienna · HIE · Hipoksja okołoporodowa · Niedotlenienie okołoporodowe · Niedotlenieniowe i niedokrwienne uszkodzenie mózgu noworodków · Noworodkowe uszkodzenie mózgu wskutek niedotlenienia i niedokrwienia |
| cs | Hypoxicko-ischemická encefalopatie | HIE · Novorozenecká hypoxie a ischemické poškození mozku · Hypoxicko-ischemické postižení mozku u novorozence |
| uk | Неонатальна гіпоксична та ішемічна травма головного мозку | HIE · Гіпоксичне та ішемічне ураження головного мозку у новонароджених · Гіпоксично-ішемічна енцефалопатія · Перинатальна гіпоксія |
| zh | 新生儿缺氧缺血性脑损伤 | 新生儿缺血缺氧性脑病 |
| tr | Yenidoğan hipoksik ve iskemik beyin hasarı | HIE · Perinatal hipoksi · Perinatal asfiksi · Hipoksik iskemik ensefalopati · Yenidoğanda hipoksik ve iskemik beyin hasarı |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | P91.6 | E | specific | validated |
| ICD-11 | KB04 | E | specific | validated |
| UMLS | C5575064 | E | validated | |
| GARD | 19875 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:71281Rare central nervous system and retinal vascular disease
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | — | Europe | Class only | Validated | European Medicines Agency 2015[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/137577
- This record as JSON: /data/d/137577.json