Tropical pancreatitis
Synonyms: TCP · Tropical calcific chronic pancreatitis
- Type
- Disease
- Group
- Disorder
- Age of onset
- Childhood
- Status
- active
A rare pancreatic disease of juvenile onset occurring mainly in tropical developing countries and characterized by chronic non-alcoholic pancreatitis manifesting with abdominal pain, steatorrhea and fibrocalculous pancreatopathy. It is also commonly associated with the development of pancreatic calculi and pancreatic cancer at a much higher frequency than seen in ordinary chronic pancreatitis.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Tropical pancreatitis | TCP · Tropical calcific chronic pancreatitis |
| fr | Pancréatite tropicale | Pancréatite tropicale calcifiante chronique · TCP |
| de | Pankreatitis, tropische | Pankreatitis, chronische kalzifizierende tropische · TCP |
| es | Pancreatitis tropical | Pancreatitis crónica tropical calcificante · TCP |
| it | Pancreatite tropicale | Pancreatite cronica calcificante tropicale · TCP |
| nl | Tropische pancreatitis | TCP · Tropische kalkvormende chronische pancreatitis |
| pt | Pancreatite tropical | |
| pl | Tropikalne zapalenie trzustki | TCP · Tropikalne wapniejące przewlekłe zapalenie trzustki |
| cs | Tropická pankreatitida | TCP · Tropická kalcifikující chronická pankreatitida |
| uk | Тропічний панкреатит | TCP · Тропічний кальцієвий хронічний панкреатит |
| zh | 热带性胰腺炎 | 热带钙化性慢性胰腺炎 |
| tr | Tropikal pankreatit | TCP · Tropikal kalsifik kronik pankreatit |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 608189 | E | validated | |
| ICD-10 | K86.1 | NTBT | attributed | validated |
| ICD-11 | DC32.5 | E | specific | validated |
| MONDO | 0011986 | E | validated | |
| MeSH | C564276 | E | validated | |
| UMLS | C1842402 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:101937Rare pancreatic disease
rare gastroenterological diseases
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:99654OBSOLETE: Fibrocalculous pancreatopathy referred to · inactive
Genes
2 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| CTRC | Major susceptibility factor in | Assessed | HGNC:2523 | ENSG00000162438 | 601405 | 1p36.21 | chymotrypsin C | 22580415[PMID]_19404200[PMID] |
| SPINK1 | Major susceptibility factor in | Assessed | HGNC:11244 | ENSG00000164266 | 167790 | 5q32 | serine peptidase inhibitor Kazal type 1 | 12360463[PMID]_12011155[PMID] |
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
12 annotations · validated 2021-11-17| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0005236 | Chronic calcifying pancreatitis | |
| HP:0410019 | Epigastric pain | |
| HP:0005213 | Pancreatic calcification | |
| Frequent (79-30%) | ||
| HP:0030992 | Abnormal pancreatic duct morphology | |
| HP:0008205 | Insulin-dependent but ketosis-resistant diabetes | |
| HP:0002018 | Nausea | |
| Occasional (29-5%) | ||
| HP:0000952 | Jaundice | |
| HP:0004395 | Malnutrition | |
| HP:0009800 | Maternal diabetes | |
| HP:0006725 | Pancreatic adenocarcinoma | |
| HP:0002013 | Vomiting | |
| HP:0001824 | Weight loss | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 25516642[PMID]_30836443[PMID]_12011155[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/103918
- This record as JSON: /data/d/103918.json