Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
Synonyms: AML and myelodysplastic syndromes related to topoisomerase type 2 inhibitor
- Type
- Disease
- Group
- Disorder
- Status
- active
A subgroup of therapy-related myeloid neoplasms (t-MN), associated with treatment of an unrelated neoplastic disease with cytotoxic agents, like etoposid, doxorubicin, daunorubicin and others. The neoplastic cells often show rearrangements involving the mixed lineage leukemia gene at 11q23. This subgroup of t-MN is typically associated with overt leukemia, without preceding myelodysplastic syndrome, developing 2-3 years after exposure, presenting with non-specific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor | AML and myelodysplastic syndromes related to topoisomerase type 2 inhibitor |
| fr | Leucémie aiguë myéloïde et syndromes myélodysplasiques liés aux inhibiteurs de la topoisomérase II | |
| de | Akute myeloische Leukämie und myelodysplastische Syndrome durch Topoisomerase Typ II-Inhibitor | AML und MDS durch Topoisomerase Typ II-Inhibitor |
| es | Leucemia mieloide aguda y síndromes mielodisplásicos relacionados con la topoisomerasa tipo 2 inhibidora | LMA y síndromes mielodisplásicos asociados al inhibidor de la topoisomerasa tipo 2 |
| it | Leucemia mieloide acuta e sindromi mielodisplastiche correlate all'inibitore della topoisomerasi tipo 2 | AML e sindromi mielodisplastiche associate all'inibitore della topoisomerasi tipo 2 |
| nl | Acute myeloïde leukemie en myelodysplastische syndromen gerelateerd aan topoisomerase type 2-remmer | AML en myelodysplastische syndromen gerelateerd aan topoisomerase type 2-remmer |
| pt | Leucemia mielóide aguda e síndromes mielodisplásticos relacionados inibidores das topoisomerases tipo II | |
| pl | Ostra białaczka szpikowa i zespoły mielodysplastyczne związane z inhibitorem topoizomerazy typu 2 | AML i zespoły mielodysplastyczne związane z inhibitorem topoizomerazy typu 2 |
| cs | Akutní myeloidní leukémie a myelodysplastický syndrom související s inhibitorem topoisomerázy typu 2 | AML a myelodysplastický syndrom související s inhibitorem topoisomerázy typu 2 |
| uk | Гострий мієлоїдний лейкоз та мієлодиспластичні синдроми, повязані з інгібітором топоізомерази 2 типу | ГМЛ та мієлодиспластичні синдроми, повязані з інгібітором топоізомерази типу 2 |
| zh | 拓扑异构酶2型抑制剂相关急性髓系白血病及骨髓增生异常综合征 | 与拓扑异构酶2型抑制物相关的急性髓系白血病和骨髓增生异常综合征 |
| tr | Topoizomeraz tip 2 inhibitörüne bağlı akut miyeloid lösemi ve miyelodisplastik sendromlar | Topoizomeraz tip 2 inhibitörü-ilişkili AML ve miyelodisplastik sendromlar |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C92.0 | NTBT | attributed | validated |
| ICD-11 | 2A60.20 | NTBT | index | validated |
| MONDO | 0015165 | E | validated | |
| UMLS | C4707659 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:86846Therapy related acute myeloid leukemia and myelodysplastic syndrome
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/102381
- This record as JSON: /data/d/102381.json